Sounds like you have the sizing done.
Keep in mind, those Sanyo spec is for an older model. You might be able to
get much better performance from newer hardware.
Heat from a source downstairs will flow up the stairs, but cooling upstairs will be a real problem.
If you use a single unit in your living room, think of it as working like
a wood stove in the same location. Will that heat your whole house?
Mine did, but it wasn't really super warm in the back bedrooms..
Nice for sleeping, but I wouldn't want to sit in there to read a book..
I would head for the warmer rooms..
One other thing to consider is the humidity/dewpoint on days when it's between 20&30F.
That will cause(& cost) you some defrost cycles. You might want to find out if anyone
in your area is using ASHPs for heating and find out about their performance.
When the dew point is running at the same temp as the air temp, it will cause defrosts.