AC_Hacker, I haven't seen you mention static pressure. You'll need to determine the static pressure your fan(s) will be presented, then cross reference that value to the fan specs to determine if the fan will meet your airflow needs.
Aside from any ducting, the core itself will cause a pressure drop. Unlike the ducting, there isn't any way to estimate this pressure drop without taking measurements. If you currently have a fan with known specs, you could set it up and take airflow or pressure measurements to establish an estimate. Otherwise, you could try finding static pressure drop ratings for commercial ERVs and use that as a base estimate.
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