Not the same at all. High molecular weight, high pressure. R410a is kind of a "high pressure extension" of R134a. Where R134a is good for Sub-Zero evaporator temperature and/or super high condensing temperature, R410a is best for HVAC system temperatures. The only advantage is that the system is physically smaller than the older refrigerant filled systems. It was pretty much invented to be different and not work well with any other gas.
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